Neuropathy

What does 12 weeks of cannabis really do for diabetic nerve pain?

💊 What Does 12 Weeks of Cannabis Really Do for Diabetic Nerve Pain?

Diabetic peripheral neuropathy (DPN) is a widespread neurological complication impacting millions worldwide. It manifests through persistent and often debilitating nerve pain, particularly in the lower extremities. A groundbreaking study has explored the effects of a novel transdermal medical cannabis formulation on this condition.

The Study at a Glance

  • A phase III, double-blind, placebo-controlled, randomized clinical trial.
  • Location: Don Chan Hospital, Thailand.
  • Duration: 12-week intervention period.
  • Participants: 100 individuals diagnosed with painful DPN.
  • Formulation: Transdermal medical cannabis (THC:CBD:CBN).

Methodology

Randomization and Allocation

Participants were randomly assigned using a computer-generated sequence to either receive the active cannabis formulation or a matched placebo. This ensures unbiased results regarding the efficacy of the treatment.

Outcome Measures

The primary measure of success was a reduction in pain intensity, evaluated through the Neuropathic Pain Symptom Inventory (NPSI-T), valid in Thai. Researchers also monitored for any treatment-emergent adverse events and dermatological changes.

Results and Interpretation

The trial yielded statistically significant reductions in NPSI-T scores for those in the treatment group, indicating considerable pain relief. This reinforces the therapeutic efficacy of the cannabis formulation in managing painful DPN.

Importantly, the participants did not experience any severe adverse effects, affirming the favorable safety profile of this innovative treatment.

Conclusion

This clinical trial supports the potential of transdermal medical cannabis as a viable therapeutic option for diabetic peripheral neuropathy. It holds promise not only for pain relief but also for improved quality of life for affected individuals. Further research is encouraged to validate these findings and expand on the treatment uses of cannabis in neuropathy.

For more information, visit the original publication:
Study on PubMed
.

Keywords: Clinical trial, Diabetic peripheral neuropathy, Painful, Transdermal medical cannabis

Yana Djonua

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