In a groundbreaking study, researchers have discovered exciting new evidence on the impact of Cannabidiol (CBD) in preventing psychosis. As a non-intoxicating component of cannabis, CBD shows anxiolytic and antipsychotic properties, alongside a strong safety profile, making it a promising candidate for addressing unmet treatment needs in individuals at clinical high risk (CHR) for psychosis.
Many individuals identified as CHR for psychosis might not progress to develop a psychotic disorder, but the interventions must be safe and well-tolerated. The recent study conducted at early detection services in the UK focused on participants showing signs of CHR, such as attenuated psychotic symptoms or brief limited intermittent psychosis.
Thirty-three antipsychotic-naïve subjects were recruited and advised against substance use prior and during the study. Using a double-blind, placebo-controlled design, subjects were randomly assigned to either a CBD or placebo group, receiving a daily dose of 600 mg CBD for 21 days.
Findings underscored that CBD treatment significantly reduced CHR symptoms and distress associated with psychotic episodes, as demonstrated by improved scores on the Comprehensive Assessment of At-Risk Mental States (CAARMS) and the Positive and Negative Syndrome Scale (PANSS).
Importantly, the incidence of treatment-emergent side effects did not differ significantly between CBD and placebo groups, reinforcing CBD’s potential as a safe treatment option. No participant from the CBD arm withdrew, showcasing its high tolerability.
While the study presents compelling results, its small sample size highlights the preliminary nature of the findings. The short treatment span of 21 days did not allow researchers to assess long-term impacts on the transition to full psychosis, necessitating further large-scale studies.
This study provides **valuable insights into the therapeutic potential of CBD** for individuals at high risk for psychosis, setting the stage for future research into its long-term benefits and clinical utility. As current pharmacological and psychological treatments for CHR individuals remain limited, CBD emerges as a promising novel treatment option.
For more details, access the full study at the source URL.
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