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    1 week ago

    Leaf Boutique
    Cannabidiol effects in stem cells: A systematic reviewStem cells play a critical role in human tissue regeneration and repair. In addition, cancer stem cells (CSCs), subpopulations of cancer cells sharing similar characteristics as normal stem cells, are responsible for tumor metastasis and resistance to chemo- and radiotherapy and to tumor relapse. Interestingly, all stem cells have cannabinoid receptors, such as cannabidiol (CBD), that perform biological functions. The aim of this systematic review was to analyze the effect of CBD on both somatic stem cells (SSCs) and CSCs. Of the 276 articles analyzed, 38 were selected according to the inclusion and exclusion criteria. A total of 27 studied the effect of CBD on SSCs, finding that 44% focused on CBD differentiation effect and 56% on its protective activity. On the other hand, 11 articles looked at the effect of CBD on CSCs, including glioblastoma (64%), lung cancer (27%), and breast cancer (only one article). Our results showed that CBD exerted a differentiating and protective effect on SCCs. In addition, this molecule demonstrated an antiproliferative effect on some CSCs, although most of the analyses were performed in vitro. Therefore, although in vivo studies should be necessary to justify its clinical use, CBD and its receptors could be a specific target to act on both SSCs and CSCs. ... See MoreSee Less

    Cannabidiol effects in stem cells: A systematic review - PubMed

    pubmed.ncbi.nlm.nih.gov

    Stem cells play a critical role in human tissue regeneration and repair. In addition, cancer stem cells (CSCs), subpopulations of cancer cells sharing similar characteristics as normal stem cells, are...
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    leafboutique2 leaf_boutique @leafboutique2 ·
    13 Dec

    Cannabidiol effects in stem cells: A systematic review

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    leafboutique2 leaf_boutique @leafboutique2 ·
    13 Dec

    Mental health and cannabidiol: an initial test: Journal of Substance Use: Vol 0, No 0

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    cannabis___chronicles

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    πŸ“° "Can a Natural Compound Really Fix Gut Damage πŸ“° "Can a Natural Compound Really Fix Gut Damage?" Highlights: 🌿 CBD oil has been found to have a positive impact on human intestinal health! πŸ’š New research reveals that cannabidiol (CBD) can enhance mitochondrial metabolism and antioxidant defenses in the intestine. πŸ”₯ This is exciting news as it could lead to new treatments for intestinal dysfunction. Here are the key findings: * CBD oil promotes AMPK phosphorylation, upregulates differentiation markers, and boosts PGC1Ξ±/SIRT3 signaling. * CBD reduces reactive oxygen species production and increases antioxidant enzymes. * CBD also increases levels of citrate, malate, and succinate, key metabolites of the tricarboxylic acid cycle. Conclusion: 🌟 CBD oil shows great promise in treating intestinal dysfunction due to its ability to enhance mitochondrial metabolic activity and antioxidant defense. Stay tuned for more updates on this exciting research! πŸ’š https://pubmed.ncbi.nlm.nih.gov/39599629/
    πŸ“° Unlocking Nature's Code: What 6 Phytochemical πŸ“° Unlocking Nature's Code: What 6 Phytochemicals Can Teach Us About Autism? πŸŒΏπŸ’‘ Discover the Power of Phytochemicals in Autism Spectrum Disorder! 🌸 Scientists have identified 6 key phytochemicals that hold therapeutic potential in managing Autism Spectrum Disorder (ASD). These natural compounds, including Cannabidiol, Crocetin, and Quercetin, target specific genes and proteins involved in ASD pathology. πŸ” The study used network pharmacology, molecular docking, and simulation studies to analyze the effects of these phytochemicals on ASD. 🧬 Key highlights: ✨ 3 out of 6 core genes are directly involved in disease pathogenesis. ✨ Phytochemicals like Cannabidiol and Resveratrol inhibit ABCG2 and ABCB1 transporters, respectively. ✨ Quercetin regulates AKR1C4 and XDH enzymes. πŸ’‘ This groundbreaking research reveals the potential of phytochemicals to regulate and modulate ASD pathology, offering new hope for managing this complex disorder. πŸ’š https://pubmed.ncbi.nlm.nih.gov/39570464/
    πŸ“° What if your body had a natural key to unlock πŸ“° What if your body had a natural key to unlocking migraine relief? πŸ’ŠπŸŒŸ Scientists are exploring this possibility with cannabinoid therapies 🌿 #MigraineResearch #CannabinoidsInMedicine Unlocking Migraine Relief: The Power of Cannabinoids πŸŒŸπŸ’Š 🌎 50 million people worldwide suffer from migraines, impacting their quality of life πŸ’‘ Recent research highlights the potential of cannabinoid targeting of immune cells as a new therapeutic target for migraine treatment Key Highlights: - Cannabinoids may modulate CGRP's effects on immune cells, leading to improved treatments - Endocannabinoids, phytocannabinoids, and synthetically derived cannabinoids show promise in reducing meningeal mast cell degranulation - Clinical trials evaluating cannabinoid-based therapies for migraines are limited but encouraging Conclusion: 🌿 Future research on the interactions between cannabinoids and immune cells could lead to more targeted and effective migraine treatments. Let's uncover the hidden key to migraine relief! πŸ”“https://doi.org/10.1186/s10194-024-01883-3
    πŸ“° Scientists discover cancer-fighting CBD compo πŸ“° Scientists discover cancer-fighting CBD compounds: a breakthrough in treatment. 🚨 Groundbreaking discovery in the fight against cancer! 🚨 Scientists have synthesized ring-annulated analogues of cannabidiol (CBD), a nonpsychoactive cannabinoid, and found them to be potent anticancer agents. πŸ’‘ These innovative compounds show promise in targeting and destroying cancer cells without harming healthy ones, making them a potential breakthrough in cancer treatment. 🌟 Highlights: - CBD-based analogues with enhanced potency against cancer cells - Targeted approach to destroy cancer cells while sparing healthy tissue - Potential for new anticancer therapies πŸŽ‰ In conclusion, this innovative research brings us one step closer to finding effective and targeted treatments for cancer patients worldwide πŸ’–. Stay tuned for more updates on this promising field of science! πŸ”¬ https://pubmed.ncbi.nlm.nih.gov/39563806/
    πŸ“° New Hope for Endometriosis Sufferers! πŸ’ŠπŸŒΏ New hope for women with Endometriosis! 🌸 Endometriosis is a chronic & incurable condition causing painful periods & fatigue, but recent advances suggest that CBD therapy may provide symptom relief! πŸ’« Highlights: - CBD has been shown to have activity in pathways contributing to endometriosis - Studies are exploring its use in clinical trials for pain management - Formulations of CBD-containing products vary, with some showing promising PK profiles πŸ“ Key points: - Endometriosis is a complex condition with limited therapeutic options - Cannabidiol (CBD) has potential as a treatment option for symptom relief - Research suggests that CBD may help manage pain and other symptoms associated with endometriosis πŸ’– Conclusion: Could cannabidiol therapy be the key to unlocking new treatments for this debilitating condition? Stay tuned for updates on this promising research! 🌟https://pubmed.ncbi.nlm.nih.gov/39547915/
    🚨 Groundbreaking Research Alert! πŸ’₯ High-dos 🚨 Groundbreaking Research Alert! πŸ’₯ High-dose chemotherapy is a common treatment for breast cancer, but it comes with a significant risk of cardiotoxicity due to the chemotherapy agent doxorubicin (DOX). Researchers have discovered that combining DOX with cannabidiol (CBD) can not only improve anticancer activity but also reduce cardiotoxic side effects! πŸ’ͺ Here are the highlights: ✨ CBD and DOX combination shows improved antitumor effect and reduced cardiotoxicity. ✨ Tumor size and weight decreased significantly in mice treated with DOX, pretreatment CBD + DOX, and CBD + DOX. ✨ Simultaneous administration of CBD and DOX increased SOD2 and reduced iNOS, MMP2, and MMP9. ✨ Cardiac histopathological examination showed no signs of congestion or inflammation in mice treated with CBD + DOX. The study concluded that combining CBD with DOX can be a game-changer for breast cancer treatment. However, more research is needed to understand the potential risks associated with CBD alone. πŸ’‘ Stay tuned for more updates on this exciting breakthrough! πŸŽ‰ https://pubmed.ncbi.nlm.nih.gov/39503169/
    πŸŒΏπŸ’‘ New Breakthrough in Alzheimer's Treatment πŸŒΏπŸ’‘ New Breakthrough in Alzheimer's Treatment! πŸŒΏπŸ’‘ **Highlights:** * CBD-rich oil shows promise as an effective treatment for Neuropsychiatric Symptoms (NPS) in Alzheimer's Disease (AD) * Reduces NPI-Q severity scores by 30% or more in just 3 months * Lowers caregiver distress levels, improving daily caregiving and emotional well-being In a groundbreaking study, researchers found that CBD-rich oil is a safe and effective therapy for treating NPS in AD patients. With no significant adverse effects reported, this natural treatment may provide relief for both patients and caregivers. The results suggest that alleviating NPS improves daily life and reduces caregiver burden, making it a promising alternative to current treatments. 🌟πŸ’ͺ This study opens doors to new possibilities in Alzheimer's treatment, providing hope for those affected by the disease. 🌟 https://pubmed.ncbi.nlm.nih.gov/39474242/
    πŸ“° "Unlocking CBD's Potential: New Hope for Alco πŸ“° "Unlocking CBD's Potential: New Hope for Alcohol Addiction Treatment" 🚨 Breakthrough in Understanding Alcohol Use Disorder 🚨 Discover how Cannabidiol (CBD) may hold the key to protecting against alcohol-related damage! πŸ’Š Researchers have found that CBD can modulate gene expression and protect human skin cells from harm caused by ethanol. Key Highlights: πŸ’‘ Low concentrations of CBD stimulate cellular metabolism and reduce cell death. 🧬 Transcriptome analysis reveals similar gene expression profiles in CBD-treated vs. control cells. 🌿 CBD impacts genes involved in extracellular matrix formation, which could aid fibrosis prevention. The study's findings suggest that CBD may be a valuable tool in preventing liver fibrosis and other complications associated with alcohol use disorder. Will CBD become the next big hope for AUD treatment? πŸ’‘ Only time will tell! https://pubmed.ncbi.nlm.nih.gov/39466591/
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